Endocrine Abstracts

Introduction: Type 2 diabetes mellitus (T2DM) is a risk factor for osteoporotic fractures although bone mineral density is increased. As such, there is a need for improved approaches to estimate fracture risk in such individuals. The Trabecular Bone Score (TBS) is a new technique to determine the trabecular bone microarchitecture.Objective: Our aim was to evaluate evaluate the usefulness of TBS in T2DM patients.Methods: We compared...

In our country, as in others, there is a lack of data on the success rate of transsphenoidal surgery for producing pituitary adenomas. We evaluated the results reported in TESSPAIN, a retrospective multicenter nationwide project that includes all the TSS performed in the participating centers in the period between 2018 and 2022, both included. Surgical treatment success is defined according to the published criteria for each disease: normal IGF-1 and GH after 75 g of oral gluc...

Aim: To evaluate the efficacy of second-line therapies in patients with acromegaly caused by a GH and PRL cosecreting pituitary neuroendocrine tumor (GH&PRL-Pit-NET) and those caused by a GH-Pit-NET.Methods: A multicenter retrospective clinical practice study of 679 patients with acromegaly in follow-up in 33 tertiary hospitals (ACRO-SPAIN study). For this analysis, only patients on treatment with pasireotide or pegvisomant in monotherapy or in combi...

Aim: To investigate the impact of pituitary surgery on glucose metabolism and to identify predictors of diabetes remission after surgery in patients with acromegaly.Methods: A national multicenter retrospective study of acromegaly patients undergoing transsphenoidal surgery for the first time at 33 tertiary Spanish hospitals (ACRO-SPAIN study, n=604) was performed. Surgical remission was evaluated according to the 2000 and 2010 criteria. Glucose...

Transsphenoidal surgery (TSS) of the hypothalamic-pituitary region is the approach of choice because of its lower morbidity compared to the transcranial approach. However, its results are highly variable and depend on many factors related to the tumor itself, to the medical team, and to technical issues. We review the situation of this procedure in a nationwide retrospective multicenter evaluation. Data were collected from centers participating in the TESSPAIN (TranssphEnoidal...